Highlights from Study Imaging

A Combined Pulmonary - Radiology Workshop for Visual Evaluation of COPD: Study Design, Chest CT Findings and Concordance with Quantitative Evaluation


During this workshop (held in February 2010), 58 pulmonologists and radiologists independently reviewed volumetric inspiratory and expiratory CT scans of 294 subjects obtained as part of COPDGene. The manuscript is in press in COPD: Journal of Chronic Obstructive Pulmonary Disease, and will be published with an online supplement displaying images from consensus cases with wide agreement on the presence and extent of COPD features on CT. The coronal images presented here offer a comparison of normal CT findings with moderately extensive centrilobular emphysema. This paper will be published in the scientific journal COPD: Journal of Chronic Obstructive Pulmonary Disease in April 2012.

Back to Top of Page


Automated Texture-Based Quantification of Centrilobular Emphysema in Chest CT Images

Results of classification for Normal No Emphysema (NNE) scan (image on left). Smoker No Emphysema (SNE) scan (middle image), and Centrilobular Emphysema (CLE) scan (image on right). ROIs colored blue were classified as normal lung, green ROIs were found to contain Centrilobular Nodularity (CN), and red ROIs were found to manifest CLE.

Back to Top of Page


COPD Exacerbations in the COPDGene Study: Associated Radiologic Phenotypes


Three-dimensional surface plots demonstrate relationships between emphysema percentage, wall thickness, and COPD exacerbation frequency (vertical axis). In a multivariate analysis adjusted for lung function, both greater lung emphysema and airway wall thickness are associated with COPD exacerbations. This paper was published in the scientific journal Radiology and may be viewed online: Click here to view published paper

Back to Top of Page