Publications

Publications Resulting from the COPDGene Project

 

A downloadable pdf listing is at the bottom of this page.

 

1.         Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lodrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB, ICGN Investigators. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009 Mar; 5:e1000421. PMID: 19300482, PMC2650282. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650282

2.         Washko GR, Dransfield MT, Estepar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC, Reilly JJ. Airway wall attenuation: A biomarker of airway disease in subjects with COPD. J Appl Physiol Jul 2009; 107:185-191. PMID: 19407254, PMC2711787. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711787

3.         Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD. Extracellular superoxide dismutase and risk of COPD. COPD 2009 Aug; 6:307-12. PMID: 19811392, PMC4075061. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075061

4.         Kindlmann GL, San Jose Estepar R, Smith SM, Westin CF. Sampling and visualizing creases with scale-space particles. IEEE Trans Vis Comput Graph 2009 Nov-Dec; 15:1415-24. PMID: 19834216, PMC2891996. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891996/

5.         Ross JC, San José Estépar R, Diaz A, Westin CF, Kikinis Ron, Silverman EK, Washko GR. Lung extraction, lobe segmentation and hierarchical region assessment for quantitative analysis on high resolution computed tomography images. Med Image Comput Comput Assist Interv 2009; 12(Pt 2):690-8. PMID: 20426172, PMC3061233. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061233/

6.         Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, Sciurba FC, Hunninghake GM, San José Estépar R, Silverman EK, Rosas IO, Hatabu H. Identification of early interstitial lung disease in smokers from the COPDGene study. Acad Radiol 2010; 17:48-53. PMID: 19781963, PMC2790552. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790552/

7.         Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD. Genetic epidemiology of COPD (COPDGene) study design. COPD 2010; 7:32-43. PMID: 20214461, PMC2924193. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924193/

8.         Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010; 42:200-202. PMID: 20173748, PMC2828499. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828499/

9.         Crapo JD. Preclinical vascular disease identifies smokers at risk for COPD. Proc Natl Acad Sci USA 2010 May; 107:8503-4. PMID: 20442330, PMC2889364. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889364/

10.         Washko GR. Diagnostic imaging in COPD. Semin Respir Crit Care Med 2010 Jun; 31:276-85. PMID: 20496297, PMC4334134. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334134/

11.         Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci USA 2010 Aug; 107:15571-6. PMID: 20713693, PMC2932580. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932580/

12.         Murphy A, Won S, Rogers A, Chu HW, Raby BA, Lange C. On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. Genet Epidemiol 2010 Sep; 34:582-90. PMID: 20718041, PMC3349936. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349936/

13.         Diaz AA, Valim C, Yamashiro T, Estépar RS, Ross JC, Matsuoka S, Bartholmai B, Hatabu H, Silverman EK, Washko GR. Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers. Chest 2010; 138:880-887. PMID: 20558554, PMC2951760. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951760

14.         Ross JC, San José Estépar R, Kindlmann G, Díaz A, Westin CF, Silverman EK, Washko GR. Automatic lung lobe segmentation using particles, thin plate splines, and maximum a posteriori estimation. Med Image Comput Assist Interv 2010; 13(Pt3):163-171. PMID: 20879396, PMC3049444. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049444/

15.         Matsuoka S, Yamashiro T, Diaz A, San Jose Estepar R, Ross JC, Silverman EK, Kobayashi Y, Dransfield MT, Bartholmai BJ, Hatabu H, Washko GR. The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis. Acad Radiol 2011 Jan; 18:40-6. PMID: 20947389, PMC3006041. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006041/

16.         Kim WJ, Hoffman E, Reilly J, Hersh C, Demeo D, Washko G, Silverman, EK. Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J 2011 Jan; 37:39-43. PMID: 20525719, PMC3074301. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074301/

17.         Yip WK, Lange C. Quantitative trait prediction based on genetic marker-array data: A simulation study. Bioinformatics 2011; 27:745-748. PMID: 21285022, PMC3105484. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105484

18.         Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO; COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011; 364:897-906. PMID: 21388308, PMC3074462. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074462/

19.         Budoff MJ, Nasir K, Kinney GL, Hokanson JE, Barr RG, Steiner R, Nath H, Lopez-Garcia C, Black-Shinn J, Casaburi R. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: Comparison of ungated and gated examinations in patients from the COPDGene cohort. J Cardiovasc Comput Tomogr 2011; 5:113-118. PMID: 21167806, PMC3075464. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075464/

20.         Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK and the COPDGene Investigators. Clinical and radiographic predictors of GOLD-unclassified smokers in COPDGene. Am J Respir Crit Care Med 2011; 184:57-63. PMID: 21493737, PMC3172890. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172890

21.         Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C. On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol 2011; 35:303-309. PMID: 21374717, PMC4096304. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096304

22.         Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL; Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-Points (ECLIPSE); Norway-Bergen cohort; National Emphysema Treatment Trial; COPD Gene investigators. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2011; 45:304-310. PMID: 21037115, PMC3266061. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266061/

23.         Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL; the COPDGene Investigators. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene study. Am J Respir Crit Care Med 2011; 184:414-420. PMID: 21562134, PMC3175544. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175544

24.         Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK, COPDGene Investigators. Family history is a risk factor for COPD. Chest 2011; 140:343-350. PMID: 21310839, PMC3198493. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198493

25.         Kim YI, Schroeder J, Lynch D, Newell J, Make B, Friedlander A, Estépar RS, Hanania NA, Washko G, Murphy JR, Wilson C, Hokanson JE, Zach J, Butterfield K, Bowler RP, COPDGene Investigators. Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD 2011; 8:285-292. PMID: 21756032, PMC3703311. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703311

26.         Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med 2011; 105:1211-1221. PMID: 21396809, PMC3116986. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116986

27.         Kim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ, COPDGene Investigators. The chronic bronchitic phenotype of COPD: an analysis of the COPDGene study. Chest 2011; 140:626-633. PMID: 21474571, PMC3168856. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168856

28.         Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR, COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene Study: associated radio­logic phenotypes. Radiology 2011; 261:274-282. PMID: 21788524, PMC3184233. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184233

29.         Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK; COPDGene Investigators; ECLIPSE Investigators. Genome-wide association study of smoking behaviors in patients with COPD. Thorax 2011; 66:894-902. PMID: 21685187, PMC3302576. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302576

30.         Castaldi PJ, Demeo DL, Hersh CP, Lomas DA, Soerheim IC, Gulsvik A, Bakke P, Rennard S, Pare P, Vestbo J, AATGM Investigators, ICGN Investigators, Silverman EK. The impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax 2011 Oct; 66:903-9. PMID: 21163806, PMC3312798. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312798/

31.         Han MK, Curran-Everett D, Dransfield MT, Criner GJ, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan EA, Make BJ, Martinez FJ, Westney GE, Foreman MG; COPDGene Investigators. Racial differences in quality of life with COPD. Chest 2011; 140:1169-1176. PMID: 21636665, PMC3205846. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205846

32.         Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK; COPDGene and ECLIPSE Investigators. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol 2011; 45:1147-1153. PMID: 21659657, PMC3262664. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262664

33.         Risholm P, Ross J, Washko GR, Wells WM. Probabilistic elastography: estimating lung elasticity. Inf Process Med Imaging 2011; 22:699-710. PMID: 21761697, PMC3249413. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249413

34.         Young RP, Hopkins RJ, Gamble GD, Etzel C, El-Zein R, Crapo JD. Genetic evidence linking lung cancer and COPD: a new perspective. Appl Clin Genet 2011; 4:99-111. PMID: 23776371, PMC3681182. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681182

35.         Qiu W, Cho MH, Riley JH, Anderson WH, Singh D, Bakke P, Gulsvik A, Litonjua AA, Lomas DA, Crapo JD, Beaty TH, Celli BR, Rennard S, Tal-Singer R, Fox SM, Silverman EK, Hersh CP; and the ECLIPSE Investigators. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One 2011; 6(9):e24395. PMID: 21949713, PMC3174957. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174957

36.         Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK; COPD Gene Investigators. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res 2011; 12:9. PMID: 21232152, PMC3033825. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033825

37.         Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP; the COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respir Res 2011; 12:127. PMID: 21951550, PMC3204243. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204243

38.         Swift I, Satti A, Kim V, Make BJ, Newell J, Steiner RM, Wilson C, Murphy JR, Silverman EK, Criner GJ; COPDGene Investigators. Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids. COPD 2012 Feb; 9:29-35. PMID: 22292596, PMC3764986. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764986

39.         Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; on behalf of the ICGN, ECLIPSE, and COPDGene Investigators. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 2012 Feb; 21:947-957. PMID: 22080838, PMC3298111. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298111

40.         Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, San Jose Estépar R, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM, the COPDGene Investigators. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 2012 Mar; 185:547-556. PMID: 22246178, PMC3297101. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297101

41.         Diaz AA, Come CE, Ross JC, San José Estépar R, Han MK, Loring SH, Silverman EK, Washko GR; COPDGene Investigators. Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest 2012 Mar; 141:736-744. PMID: 21940776, PMC3296457. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296457

42.         Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H. Kosas IO, Hunninghake GM, COPDGene Investigators. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med 2012 Apr; 185:756-762. PMID: 22268134, PMC3326424. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326424

43.         Christoforou A, Dondrup Michael, Mattingsdal M, Mattheisen M, Giddaluru S, Nothen MM, Rietschel M, Cichon S, Djurovic S, Andreassen IA, Jonassen I, Steen VM, Puntervoll P, Le Hellard S. Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet 2012 Apr; 90:727-33. PMID: 22444669, PMC3322240. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322240

44.         Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R; the COPDGene Investi­gators. Six-minute walk distance predictors, including CT scan measures, in the COPDGene Cohort. Chest 2012 Apr; 141:867-875. PMID: 21960696, PMC3318949. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318949

45.         COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD 2012 Apr; 9:151-159. PMID: 22429093, PMC3752926. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752926

46.         Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, Washko GR, Martinez FJ, Han MK; COPDGene Investigators. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax 2012 May; 67:399-406. PMID: 22514236, PMC3719874. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719874

47.         Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol 2012 Jul; 36:419-429. PMID: 22549767, PMC3641852. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641852

48.         Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ. Genetic association between human chitinases and lung function in COPD. Hum Genet 2012 Jul; 131:1105-14. PMID: 22200767, PMC3771523. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771523

49.         Stewart JI, Moyle S, Criner GJ, Wilson C, Tanner R, Bowler RP, Crapo JD, Zeldin RK, Make BJ, Regan EA, for the COPDGene Investigators. Automated tele­communication to obtain longitudinal follow-up in a multicenter cross-sectional COPD study. COPD 2012 Aug; 9:466-72. PMID: 22676387, PMC3698488. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698488

50.         Sieren JP, Newell JD, Judy PF, Lynch DA, Chan KS, Guo J, Hoffman EA. Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study. Med Phys 2012 Sep; 39:5757-5767. PMID: 22957640, PMC3448623. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448623

51.         Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT; COPDGene Investigators; ECLIPSE Study Investigators. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 2012 Sep; 367:913-921. PMID: 22938715, PMC 3690810. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690810

52.         Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med 2012 Oct; 186:622-32. PMID: 22837378, PMC3480517. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517

53.         Ginsburg SB, Lynch DA, Bowler RP, Schroeder JD. Automated texture-based quantification of centrilobular nodularity and centrilobular emphysema in chest CT images. Acad Radiol 2012 Oct; 19:1241-1251. PMID: 22958719, PMC3679917. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679917

54.         Zach JA, Newell JD Jr, Schroeder J, Murphy JR, Curran-Everett D, Hoffman EA, Westgate PM, Han MK, Silverman EK, Crapo JD, Lynch DA, COPDGene Investigators. Quantitative CT of the lungs and airways in healthy non-smoking adults. Invest Radiol 2012 Oct; 47:596-602. PMID: 22836310, PMC3703944. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703944

55.         Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD. CT-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med 2012 Nov; 18:1711-1715. PMID: 23042237, PMC3493851. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493851

56.         Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agusti A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK; on behalf of the ECLIPSE, ICGN, and COPDGene Investigators. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012 Dec; 186:1238-1247. PMID: 23144326, PMC3622441. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622441

57.         Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics 2012 Dec; 28:3027-33. PMID: 23044548, PMC3516147. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516147

58.         Qiao D, Yip WK, Lange C. Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics 2012; 13:100. PMID: 22591016, PMC3434015. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434015

59.         Mendoza CS, Washko GR, Ross JC, Díaz AA, Lynch DA, Crapo JD, Silverman EK, Begoña A, Serrano-Gotarredona C, Estépar RS. Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging 2012; 2012:474-477. PMC3670097. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670097

60.         Estépar RS, Ross JC, Kindlmann GL, Díaz A, Okajima Y, Kikinis R, Westin CR, Silverman EK, Washko GR. Automatic airway analysis for genome-wide association studies in COPD. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging 2012; 2012:1467-1470. PMC3670103. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670103

61.         Estépar RS, Ross JC, Krissian K, Schultz T, Washko GR, Kindlmann G. Compu­tational vascular morphometry for the assessment of pulmonary vascular disease based on scale-space particles. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging. 2012; pp 1479-1482. PMC3670102. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670102

62.         Kurugol S, San Jose Estepar R, Ross J, Washko GR. Aorta segmentation with a 3D level set approach and quantification of aortic calcifications in non-contrast chest CT. Conf Proc IEEE Eng Med Biol Soc 2012; 2012:2343-6. PMID: 23366394, PMC3671590. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671590

63.         Silverman EK, Loscalzo J. Developing new drug treatments in the era of network medicine. Clin Pharmacol Ther 2013 Jan; 93:26-8. PMID: 23212105, PMC3545395. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545395

64.         Hansel N, Washko G, Foreman M, Han M, Hoffman E, DeMeo D, Barr G, Van Beek E, Kazerooni E, Wise R, Brown R, Black-Shinn J, Hokanson J, Hanania N, Make B, Silverman B, Crapo J, Dransfield M. Racial differences in CT phenotypes in COPD. COPD 2013 Feb; 10(1):20-7. PMID: 23413893, PMC4321889. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321889

65.         Kim SS, Seo JB, Lee HY, Nevrekar DV, Forssen AV, Crapo JD, Schroeder JD, Lynch DA. Chronic obstructive pulmonary disease: lobe-based visual assess­ment of volumetric CT by using standard images - comparison with quantitative CT and pulmonary function test in the COPDGene study. Radiology 2013 Feb; 266(2):626-35. PMID: 23220894, PMC3558873. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558873

66.         Han MK, Muellerova H, Curran-Everett D, Dransfield MT, Washko GR, Regan EA, Bowler RP, Beaty TH, Hokanson JE, Lynch DA, Jones PW, Anzueto A, Martinez FJ, Crapo JD, Silverman EK, Make BJ. GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med 2013 Mar; 1:43-50. PMID: 24321803, PMC4105297. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105297

67.         Diaz AA, Han MK, Come CE, San José Estépar R, Ross JC, Kim V, Dransfield MT, Curran-Everett D, Schroeder JD, Lynch DA, Tschirren J, Silverman EK, Washko GR. Effect of emphysema on CT scan measures of airway dimensions in smokers. Chest 2013 Mar; 143(3):687-93. PMID: 23460155, PMC3590885. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590885

68.         Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK; and the COPDGene and ECLIPSE Investigators. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet 2013 Apr; 132:431-41. PMID: 23299987, PMC3600068. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600068

69.         Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AMK, Quackenbush J, Silverman EK. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics 2013 May; 101:263-72. PMID: 23459001, PMC3659826. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659826

70.         Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Cogan JD, Mason WR, Maher TM, Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Smith K, McKean D, Pedersen BS, Talbert J, Kidd RN, Markin CR, Beckman KB, Lathrop M, Schwarz MI, Schwartz DA. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet 2013 Jun; 45(6):613-20. PMID: 23583980, PMC3677861. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677861

71.         Come CE, Diaz AA, Curran-Everett D, Muralidhar N, Hersh CP, Zach JA, Schroeder J, Lynch DA, Celli B, Washko GR. Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest 2013 Jun; 143(6):1607-17. PMID: 23699785, PMC3673661. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673661/

72.         Lutz SM, Fingerlin T, Fardo DW. Statistical Approaches to Combine Genetic Association Data. J Biom Biostat 2013 Jun; 4:1000166. PMID: 24009987, PMC3760734. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760734

73.         Estépar RS, Kinney GL, Black-Shinn JL, Bowler RP, Kindlmann GL, Ross JC, Kikinis R, Han MK, Come CE, Diaz A, Cho MH, Hersh CP, Schroeder JD, Reilly JJ, Lynch DA, Crapo JD, Wells JM, Dransfield MT, Hokanson JE, Washko GR; for the COPDGene Study. Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. Am J Respir Crit Care Med 2013 Jul; 188(2):231-39. PMID: 23656466, PMC3778757. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778757

74.         Qiao D, Mattheisen M, Lange C. On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis - Topt: an outlier detection method. Genet Epidemiol 2013 Jul; 37:431-9. PMID: 23674291, PMC3918437. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918437

75.         Bahr TM, Hughes GJ, Armstrong M, Reisdorph R, Coldren CD, Edwards MG, Schnell C, Kedl R, Laflamme DJ, Reisdorph N, Kechris KJ, Bowler RP. Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2013 Aug; 49(2):316-23. PMID: 23590301, PMC3824029. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824029

76.         Carolan BJ, Kim Y, Williams AA, Kechris K, Lutz S, Reisdorph N; Bowler RP. The association of adiponectin with computed tomography phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013 Sep; 188:561-6. PMID: 23777323, PMC3827701. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827701

77.         Schroeder JD, McKenzie AS, Zach JA, Wilson CG, Curran-Everett D, Stinson DS, Newell JD Jr, Lynch DA. Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping and airways in smokers with and without COPD. AJR Am J Roentgenol 2013 Sep; 201(3):W460-70. PMID: 23971478, PMC4067052. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067052/

78.         Lynch DA, Al-Qaisi MA. Quantitative computed tomography in chronic obstructive pulmonary disease. J Thorac Imaging 2013 Sep; 28:284-90. PMID: 23748651, PMC4161463. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161463

79.         Zhou JJ, Cho MH, Castaldi PJ, Hersh CP, Silverman EK, Laird NM. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med 2013 Oct; 188(8):941-7. PMID: 23972146, PMC3826281. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826281

80.         Castaldi PJ, San José Estépar R, Mendoza CS, Hersh CP, Laird N, Crapo JD, Lynch DA, Silverman EK, Washko GR. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med 2013 Nov; 188(9):1083-90. PMID: 23980521, PMC3863741. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863741

81.         Lutz S, Yip WK, Hokanson J, Laird N, Lange C. A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet 2013; 14:13. PMID: 23448186, PMC3648382. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648382

82.         Zulueta-Coarasa T, Kurugol S, Ross JC, Washko G, San Jose Estepar R. Emphysema classification based on embedded probabilistic PCA. Conf Proc IEEE Eng Med Biol Soc 2013; 2013:3969-72. PMID: 24110601, PMC3918501. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918501

83.         Hersh CP, Washko GR, Estépar RS, Lutz S, Friedman PJ, Han MK, Hokanson JE, Judy PF, Lynch DA, Make BJ, Marchetti N, Newell JD Jr, Sciurba FC, Crapo JD, Silverman EK; COPDGene Investigators. Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res 2013; 14:42. PMID: 23566024, PMC3627637. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627637

84.         Aminuddin F, Hackett TL, Stefanowicz D, Saferali A, Paré PD, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Silverman EK, Sandford AJ. Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease. BMC Pulm Med 2013 Nov 6; 13:64. PMID: 24192154, PMC3827989. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827989

85.         Lutz SM, Vansteelandt S, Lange C. Testing for direct genetic effects using a screening step in family-based association studies. Front Genet 2013 Nov 21; 4:243. PMID: 24312120, PMC3836057. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836057

86.         Ross JC, Kindlmann GL, Okajima Y, Hatabu H, Diaz AA, Silverman EK, Washko GR, Dy J, San Jose Estepar R. Pulmonary lobe segmentation based on ridge surface sampling and shape model fitting. Med Phys 2013 Dec; 40:121903. PMID: 24320514, PMC3843757. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843757

87.         Bowler RP, Bahr T, Hughes G, Lutz S, Kim YI, Coldren CD, Residorph N, Kechris KJ. Integrative omics approach identifies interleukin-16 as a biomarker of emphysema. OMICS 2013 Dec; 17:619-26. PMID: 24138069, PMC3837437. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837437

88.         Qiao D, Cho MH, Fier H, Bakke PS, Gulsvik A, Silverman EK, Lange C. On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. Bioinformatics 2014 Jan; 30:157-64. PMID: 24262215, PMC3892690. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892690

89.         Manichaikul A; Hoffman EA, Smolonska J; Gao W, Cho MH, Baumhauer H, Budoff M, Austin JHM, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJM, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS, Barr RG. Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Athero­sclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med 2014 Feb 15; 189:408-418. PMID: 24383474, PMC3977717. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977717

90.         Kinney GL, Black-Shinn J, Wan ES, Make B, Regan E, Lutz S, Soler X, Silverman EK, Crapo J, Hokanson JE, the COPDGene Investigators. Pulmonary function reduction in diabetes mellitus with and without chronic obstructive pulmonary disease. Diabetes Care 2014 Feb; 37(2):389-95. PMID: 24026562, PMC3898761. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898761

91.         Cho MH, McDonald MN, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, DeMeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Murray T, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, on behalf of the ICGN, ECLIPSE, and COPDGene Investigators. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2014 Mar; 2:214-225. PMID: 24621683, PMC4176924. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176924

92.         Bhatt SP, Kim YI, Wells JM, Bailey WC, Ramsdell JW, Foreman MG, Jensen RL, Stinson DS, Wilson CG, Lynch DA, Make BJ, Dransfield MT. FEV1/FEV6 to diagnose airflow obstruction: comparisons with computed tomography and morbidity indices. Ann Am Thorac Soc 2014 Mar; 11(3):335-41. PMID: 24450777, PMC4028741. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028741

93.         Martinez CH, Kim V, Chen Y, Kazerooni EA, Murray S, Criner GJ, Curtis JL, Regan EA, Wan E, Hersh CP, Silverman EK, Crapo JD, Martinez FJ, Han MK, and the COPDGene Investigators. The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med 2014; 108:491-499. PMID: 24280543, PMC3943716. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943716

94.         Washko GR, Diaz AA, Kim V, Barr RG, Dransfield MT, Schroeder J, Reilly KK, Ramsdell JW, McKenzie A, Van Beek EJ, Lynch DA, Butler JP, Han MK. Computed tomographic measures of airway morphology in smokers and never-smoking normals. J Appl Physiol (1985) 2014 Mar 15; 116(6):668-73. PMID: 24436301, PMC3949240. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949240

95.         Nava R, Escalante-Ramírez B, Cristóbal G, San José Estépar R. Extended Gabor approach applied to classification of emphysematous patterns in computed tomography. Med Biol Eng Comput 2014 Apr; 52(4):393-403. PMID: 24496558, PMC4254807. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254807

96.         Kim V, Davey A, Comellas AP, Han MK, Washko G, Martinez CH, Lynch D, Lee JH, Silverman EK, Crapo JD, Make BJ, Criner GJ, and the COPDGene Investigators. Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. Respir Res 2014 Apr 27; 15(1):52. PMID: 24766722, PMC4067738. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067738

97.         Kurugol S, Washko GR, San José Estépar R. Ranking and classification of monotonic emphysema patterns with a multi-class hierarchical approach. Proc IEEE Int Symp Biomed Imaging 2014 Apr-May; 2014:1031-1034. PMID: 25485040, PMC4254822. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254822

98.         Bhatt SP, Sieren JC, Dransfield MT, Washko GR, Newell JD Jr, Stinson DA, Zamba GK, Hoffman EA; for the COPDGene Investigators. Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax 2014 May; 69(5):409-14. PMID 23525095, PMC4146523. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146523

99.         Castaldi PJ, Dy J, Ross JC, Chang Y, Washko GR, Curran-Everett D, Williams A, Lynch DA, Make BJ, Crapo JD, Bowler RP, Regan EA, Hokanson JE, Kinney GL, Han MK, Soler X, Ramsdell JR, Barr RG, Foreman MG, van Beek EJ, Casaburi R, Criner GJ, Lutz SM, Rennard SI, Santorico S, Sciurba FC, Hersh CP, Silverman EK, Cho MH. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax 2014 May; 69(5):415-22. PMID: 24563194, PMC4004338. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004338/

100.         Kim SS, Yagihashi K, Stinson DS, Zach JA, McKenzie AS, Curran-Everett D, Wan ES, Silverman EK, Crapo JD, Lynch DA. Visual assessment of CT findings in smokers with nonobstructed spirometric abnormalities in the COPDGene study. Chronic Obstr Pulm Dis (Miami) May 2014; 1(1):88-96. PMID: 25197723, PMC4153727. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153727

101.         Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN and the COPDGene Investigators. Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. Chronic Obstr Pulm Dis (Miami) May 2014; 1(1):105-114. PMID: 25695106, PMC4329763. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329763

102.         Sverzellati N, Lynch DA, Pistolesi M, Kauczor HU, Grenier PA, Wilson C, Crapo JD, on behalf of COPDGene CT Workshop Group. Physiologic and quantitative computed tomography differences between centrilobular and panlobular emphysema in COPD. Chronic Obstr Pulm Dis (Miami) 2014 May; 1(1):125-132. PMC4447143. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447143

103.         Martinez CH, Okajima Y, Murray S, Washko GR, Martinez FJ, Silverman EK, Lee JH, Regan EA, Crapo JD, Curtis JL, Hatabu H, Han MK, COPDGene Investigators. Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res 2014 Jun 3; 15:62. PMID: 24894541, PMC4049804. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049804

104.         Chu JH, Hersh CP, Castaldi PJ, Cho MH, Raby BA, Laird N, Bowler R, Rennard S, Loscalzo J, Quakenbush J. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol 2014 Jun 25; 8:78. PMID: 24964944, PMC4105829. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105829/

105.         Lutz SM, Hokanson JE, Lange C. An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies. Front Genet 2014 Jul 1; 5:188. PMID: 25071819, PMC4076613. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076613/

106.         Bhatt SP, Sieren JC, Newell JD, Comellas AP, Hoffman EA. Disproportionate contribution of right middle lobe to emphysema and gas trapping on computed tomography. PLoS One 2014 Jul 23; 9(7):e102807. PMID: 25054539, PMC4108372. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108372

107.         Hardin M, Cho M, McDonald ML, Beaty T, Ramsdell J, Bhatt S, van Beek EJ, Make BJ, Crapo JD, Silverman EK, Hersh CP. The clinical and genetics features of COPD asthma overlap syndrome. Eur Respir J 2014 Aug; 44(2):341-50. PMID 24876173, PMC4154588. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154588/

108.         Wan ES, Castaldi PJ, Cho MH, Hokanson JE, Regan EA, Make BJ, Beaty TH, Han MK, Curtis JL, Curran-Everett D, Lynch DA, DeMeo DL, Crapo JD, Silverman EK, and the COPDGene Investigators. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res 2014 Aug 6; 15(1):89. PMID: 25096860, PMC4256936. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256936/

109.         Kim V, Desai P, Newell Jr JD, Make BJ, Washko GR, Silverman EK, Crapo JD, Bhatt SP, Criner GJ. Airway wall thickness is increased in COPD patients with broncho­dilator reversibility. Respir Res 2014 Aug 8; 15(1):84. PMID: 25248436, PMC4198908. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198908

110.         Castaldi PJ, Cho MH, San José Estépar R, McDonald ML, Laird N, Beaty TH, Washko G, Crapo JD, Silverman EK, COPDGene Investigators. Genome-wide association identifies regulatory loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med 2014 Aug 15; 190(4):399-409. PMID: 25006744, PMC4214129. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214129

111.         Lee JH, McDonald ML, Cho MH, Wan ES, Castaldi PJ, Hunninghake GM, Marchetti N, Lynch DA, Crapo JD, Lomas DA, Coxson HO, Bakke PS, Silverman EK, Hersh CP and the COPDGene and ECLIPSE Investigators. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res 2014 Aug 20; 15(1):97. PMID: 25134640, PMC4169636. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169636/

112.         McDonald ML, Mattheisen M, Cho MH, Liu YY, Harshfield B, Hersh CP, Bakke P, Gulsvik A, Lange C, Beaty TH, Silverman EK. Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered 2014 Aug 27; 78(3-4):131-139. PMID: 25171373, PMC4415367. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415367/

113.         Black-Shinn JL, Kinney GL, Wise AL, Regan EA, Make B, Krantz MJ, Barr RG, Murphy JR, Lynch D, Silverman EK, Crapo JD, Hokanson JE and the COPDGene Investigators. Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD 2014 Sep; 11(5):546-51. PMID: 24831864, PMC4467820. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467820

114.         Lee J, Cho MH, Hersh CP, McDonald ML, Crapo JD, Bakke PS, Gulsvik A, Comellas AP, Wendt CH, Lomas DA, Kim V, Silverman EK. Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. Respir Res 2014 Sep 21; 15(1):113. PMID: 25241909, PMC4190389. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190389/

115.         Kim V, Goel N, Gangar J, Zhao H, Ciccolella DE, Silverman EK, Crapo JD, Criner GJ, and the COPDGene Investigators. Risk factors for venous thromboembolism in chronic obstructive pulmonary disease. Chronic Obstr Pulm Dis (Miami) 2014 Sept 26; 1(2):239-249. PMID: 25844397, PMC4382082. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382082

116.         Lutz SM, Hokanson JE. Genetic influences on smoking and clinical disease. Understanding behavioral and biological pathways with mediation analysis. Annals Am Thorac Soc 2014 Sept; 11(7):1082-3 (invited editorial). PMID: 25237988, PMC4214059. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214059/

117.         Batmanghelich KN, Cho M, Jose RS, Golland P. Spherical topic models for imaging phenotype discovery in genetic studies. Bayesian Graph Models Biomed Imaging 2014; 8677:107-117. PMID: 25717477, PMC4337963. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337963/

118.         Bowler RP, Kim V, Regan E, Williams A, Santorico SA, Make BJ, Lynch DA, Hokanson JE, Washko GR, Bercz P, Soler X, Marchetti N, Criner G, Ramsdell J, Han MK, Demeo D, Anzueto A, Comellas A, Crapo JD, Dransfield M, Wells J, Hersh CP, MacIntyre N, Martinez F, Nath H, Niewoehner D, Sciurba F, Sharafkhaneh A, Silverman EK, Van Beek EJR, Wilson C, Wendt C, Wise RA for the COPDGene Investigators. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest 2014 Oct; 146(4):941-50. PMID: 24945159, PMC4188150. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188150/

119.         Marchetti N, Garshick E, Kinney GL, McKenzie A, Stinson D, Lutz S, Lynch DA, Criner GJ, Silverman EK, Crapo JD, and the COPDGene Investigators. Association between occupational exposure and lung function, respiratory symptoms and high resolution CT imaging in COPDGene. Am J Respir Crit Care Med 2014 Oct 1; 190(7):756-62. PMID: 25133327, PMC4299608. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299608/

120.         Lee JH, Cho MH, McDonald MN, Hersh CP, Castaldi PJ, Crapo JD, Wan ES, Dy JG, Chang Y, Regan EA, Hardin M, DeMeo DL, Silverman EK and the COPDGene Investigators. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med 2014 Oct; 108(10):1469-80. PMID: 25154699, PMC4253548. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253548/

121.         Hersh CP, Make BJ, Lynch DA, Barr RG, Bowler RP, Calverley PM, Castaldi PJ, Cho MH, Coxson HO, DeMeo DL, Foreman MG, Han MK, Harshfield BJ, Hokanson JE, Lutz S, Ramsdell JW, Regan EA, Rennard SI, Schroeder JD, Sciurba FC, Steiner RM, Tal-Singer R, van Beek EJ, Silverman EK, Crapo JD; the COPDGene and ECLIPSE Investigators. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med 2014 Oct 24; 14(1):164. PMID: 25341556, PMC4216374. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216374

122.         Parker MM, Foreman MG, Abel HJ, Mathias RA, Hetmanski JB, Crapo JD, Silverman EK, Beaty TH; the COPDGene Investigators. Admixture mapping identifies a quantitative trait locus associated with FEV1 /FVC in the COPDGene study. Genet Epidemiol 2014 Nov; 38(7):652-59. PMID: 25112515, PMC4190160. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190160/

123.         McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi P, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2014 Nov; 51(5):678-87. PMID: 24825563, PMC4224086. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224086/

124.         Bhatt SP, Wells JM, Kim V, Criner GJ, Hersh CP, Hardin M, Bailey WC, Nath H, Kim Y, Foreman MG, Stinson DS, Wilson CG, Rennard SI, Silverman EK, Barry BJ, Dransfield MT. Radiological correlates and clinical implications of the paradoxical lung function response to beta2-agonists: an observational study. Lancet Respir Med 2014 Nov; 2(11):911-8. PMID: 25217076, PMC4306040. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306040/

125.         Diaz AA, Hardin ME, Come CE, Estépar RS, Ross JC, Kurugol S, Okajima Y, Han MK, Kim V, Ramsdell J, Silverman EK, Crapo JD, Lynch DA, Make BJ, Barr RG, Hersh CP, Washko GR, for the COPDGene Investigators. Childhood-onset asthma in smokers: Association between CT measures of airway size, lung function and COPD. Ann Am Thorac Soc 2014 Nov; 11(9):1371-8. PMID: 25296268, PMC4298990. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298990/

126.         Hobbs BD, Foreman MG, Bowler R, Jacobson F, Make BJ, Castaldi PJ, San José Estépar R, Silverman EK, Hersh CP, the COPDGene Investigators. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc 2014 Nov; 11(9):1387-94. PMID: 25295410, PMC4298989. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298989/

127.         Putcha N, Puhan MA, Drummond MB, Han MK, Regan EA, Hanania NA, Martinez C, Foreman M, Bhatt SP, Make BJ, Ramsdell J, Demeo D, Barr RG, Rennard SI, Martinez F, Silverman EK, Crapo JD, Wise RA, Hansel NN. A simplified score to quantify comorbidity in COPD. PLOS One 2014 Dec 16; 9(12):e114438. PMID: 25514500, PMC4267736. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267736/

128.         Dijkstra AE, Boezen HM, van den Berge M, Vonk JM, Hiemstra PS, Barr RG, Burkart KM, Manichaikul A, Pottinger TD, Silverman EK, Cho MH, Crapo JD, Beaty TH, Bakke P, Gulsvik A, Lomas DA, Bossé Y, Nickle DC, Paré PD, de Koning HJ, Lammers JW, Zanen P, Smolonska J, Wijmenga C, Brandsma CA, Groen HJM, Postma DS, the LifeLines Cohort Study group. Dissecting the genetics for chronic mucus hypersecretion in smokers with and without COPD. Eur Respir J 2015 Jan; 45(1):60-75. PMID: 25234806, PMC4498483. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498483

129.         Park SJ, Foreman MG, DeMeo DL, Bhatt SP, Hansel NN, Wise RA, Soler X, Bowler RP. Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities and CT metrics. Respirology 2015 Jan; 20(1):108-14. PMID: 25328036, PMC4415502. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415502

130.         Newell JD Jr, Fuld MK, Allmendinger T, Sieren JP, Chan KS, Guo J, Hoffman EA. Very low-dose (0.15 mGy) chest CT protocols using the COPDGene 2 test object and a third-generation dual-source CT scanner with corresponding third-generation iterative reconstruction software. Invest Radiol 2015 Jan; 50(1): 40-45. PMID: 25198834, PMC4294320. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294320/

131.         Bowler RP, Jacobson S, Cruickshank C, Hughes GJ, Siska C, Ory DS, Petrache I, Schaffer JE, Reisdorph N, Kechris K. Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes. Am J Respir Crit Care Med 2015 Feb 1; 191(3):275-84. PMID: 25494452, PMC4351578. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351578/

132.         Stanley SE, Chen JJ, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, Qi X, Rafaels NM, Wise RA, Silverman EK, Barnes KC, Armanios M. Telomerase mutations in smokers with severe emphysema. J Clin Invest 2015 Feb; 125(2):563-70. PMID: 25562321, PMC4319417. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319417

133.         Diaz AA, Young TP, Kurugol S, Eckbo E, Muralidhar N, Chapman JK, Kinney GL, Ross JC, Estepar RSJ, Harmouche R, Black-Shinn JL, Budoff M, Bowler RP, Hokanson J, Washko GR for the COPDGene investigators. Abdominal visceral adipose tissue is associated with myocardial infarction in patients with COPD. Chronic Obstr Pulm Dis (Miami) 2015 Feb; 2:262-270. PMID: 25914898, PMC4408419. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408419/

134.         Castaldi PJ, Cho MH, Zhou X, Qiu W, McGeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley J, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet 2015 Feb 15; 24(4):1200-10. PMID: 25315895, PMC4806382. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806382

135.         Diaz AA, Rahaghi F, Ross JC, Harmouche R, Tschirren J, San Jose Estepar R, Washko GR, for the COPDGene Investigators. Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers. Respir Res 2015 Feb 15; 16(1):23. PMID: 25848985, PMC4335784. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335784

136.         Kim V, Crapo JD, Zhao H, Jones PW, Silverman EK, Comellas A, Make BJ, Criner GJ, and the COPDGene Investigators. Comparison between an alternative and the classic definition of chronic bronchitis in the COPDGene study. Ann Am Thorac Soc 2015 Mar 1; 12(3):332-339. PMID: 25575351, PMC4418311. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418311/

137.         Lee JH, Cho MH, Hersh CP, McDonald MN, Wells JM, Dransfield MT, Bowler RP, Lynch DA, Lomas DA, Crapo JD, Silverman EK on behalf of the COPDGene and ECLIPSE Investigators. IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2015 Mar; 52(3):365-376. PMID: 25101718, PMC4370263. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370263/

138.         McDonald MN, Diaz AA, Ross JC, San Jose Estepar R, Zhou L, Regan EA, Eckbo E, Muralidhar N, Come CE, Cho MH, Hersh CP, Lange C, Wouters E, Casaburi RH, Coxson HO, MacNee W, Rennard SI, Lomas DA, Agusti A, Celli BR, Black-Shinn JL, Kinney GL, Lutz SM, Hokanson JE, Silverman EK, Washko GR, for the ECLIPSE and COPDGene Investigators. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc 2014 Mar; 11(3): 326-334. PMID: 24558953, PMC4028743. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028743

139.         Chen W, Brehm JM, Manichaikul A, Cho MH, Boutaoui N, Yan Q, Burkart KM, Enright PL, Rotter JI, Petersen H, Leng S, Obeidat M, Bossé Y, Brandsma CA, Hao K, Rich SS, Powell R, Avila L, Soto-Quiros M, Silverman EK, Tesfaigzi Y, Barr RG, Celedón JC. A genome-wide association study of chronic obstructive pulmonary disease in Hispanics. Ann Am Thorac Soc 2015 Mar; 12(3):340-8. PMID: 25584925, PMC4418314. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418314

140.         Koeverden IV, Blanc PD, Bowler RP, Arjomandi M. Secondhand tobacco smoke & COPD risk in smokers: a COPDGene study cohort subgroup analysis. COPD 2015 Apr; 12(2):182-9. PMID: 24983136, PMC4820340. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820340/

141.         Jaramillo JD, Wilson C, Stinson DJ, Lynch DA, Bowler RP, Lutz S, Bon JM, Arnold B, McDonald MN, Washko GR, Wan ES, DeMeo DL, Foreman MG, Soler X, Lindsay SE, Lane NE, Genant HK, Silverman EK, Hokanson JE, Make BJ, Crapo JD, Regan EA and the COPDGene investigators. Reduced bone density and vertebral fractures in smokers: men and COPD patients at increased risk. Ann Am Thorac Soc 2015 May 1; 12(5):648-656. PMID: 25719895, PMC4418341. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418341/

142.         Wells JM, Iyer AS, Rahaghi FN, Bhatt S, Gupta H, Denney TS, Lloyd SG, Dell'Italia LJ, Nath H, Estepar RS, Washko GR, Dransfield MT. Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. Circ Cardiovasc Imaging 2015 Apr; 8:e002546. PMID: 25855668, PMC4392846. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392846/

143.         Chen LS, Hung RJ, Baker T, Horton A, Culverhouse R, Saccone N, Cheng I, Deng B, Han Y, Hansen HM, Horsman J, Kim C, Lutz S, Rosenberger A, Aben KK, Andrew AS, Breslau N, Chang S, Dieffenbach AK, Dienemann H, Frederiksen B, Han J, Hatsukami DK, Johnson EO, Pande M, Wrensch MR, McLaughlin J, Skaug V, van der Heijden HF, Wampfler J, Wenzlaff A, Woll P, Zienolddiny S, Bickeböller H, Brenner H, Duell EJ, Haugen A, Heinrich J, Hokanson JE, Hunter DJ, Kiemeney LA, Lazarus P, Le Marchand L, Liu G, Mayordomo J, Risch A, Schwartz AG, Teare D, Wu X, Wiencke JK, Yang P, Zhang Z, Spitz MR, Kraft P, Amos CI, Bierut LJ. CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis - meta-analysis. J Natl Cancer Inst 2015 Apr 14; 107(5): pii: djv100. PMID: 25873736, PMC4822525. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822525/

144.         Wan ES, Qiu W, Morrow J, Beaty TH, Hetmanski J, Make BJ, Lomas DA, Silverman EK, DeMeo DL. Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. Mol Reprod Dev 2015 May; 82(5):377-86. PMID: 25988574, PMC4439255. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439255/

145.         Batmanghelich NK, Saeedi A, Cho M, Estepar RS, Golland P. Generative method to discover genetically driven image biomarkers. Inf Process Med Imaging 2015 Jul; 24:30-42. PMID: 26221665, PMC4527679. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527679/

146.         Wan ES, Qiu W, Carey VJ, Morrow J, Bacherman H, Foreman MG, Hokanson JE, Bowler RP, Crapo JD, DeMeo DL. Smoking associated site-specific methylation in buccal mucosa in the COPDGene study. Am J Respir Crit Cell Mol Biol 2015 Aug; 53(2):246-254. PMID: 25517428, PMC4566042. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566042/

147.         Park SJ, Make B, Hersh CP, Bowler RP. Significance of medication history at the time of entry into the COPDGene study: relationship with exacerbation and CT metrics. COPD 2015 Aug; 12(4):366-373. PMID: 25254928, PMC4620928. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620928/

148.         Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, Bakke P, Gulsvik A, San José Estépar R, Van Beek EJR, Coxson HO, Lynch DA, Washko GR, Laird NM, Crapo JD, Beaty TH, Silverman EK, on behalf of the NETT Genetics, ECLIPSE, and COPDGene Investigators. A genome-wide association study of emphysema and airway quantitative imaging phenotypes. Am J Respir Crit Care Med 2015 Sept 1; 192(5):559-569. PMID: 26030696, PMC4595690. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595690/

149.         Meek P, Petersen H, Washko GR, Diaz AA, Kim V, Sood A, Tesfaigzi Y. Chronic bronchitis is associated with worse symptoms and quality of life than chronic airflow obstruction. Chest 2015 Aug 1; 148(2):408-16. PMID: 25741880, PMC4524327. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524327/

150.         Kurugol S, Come CE, Diaz AA, Ross JC, Kinney GL, Black-Shinn JL, Hokanson JE, Budoff MJ, Washko GR, San Jose Estepar R. Automated quantitative 3D analysis of aorta size, morphology, and mural calcification distributions. Med Phys 2015 Sept; 42(9):5467. PMID: 26328995, PMC4552704. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552704/

151.         Boes JL, Bule M, Hoff BA, Chamberlain R, Lynch DA, Stoganovska J, Martinez FJ, Han MK, Kazerooni EA, Ross BD, Galbán CJ. The impact of sources of variability on parametric response mapping of lung CT scans. Tomography 2015 Sept; 1(1):69-77. PMID: 26568983, PMC4643661. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643661/

152.         Regan EA, Lynch DA, Curren-Everett D, Curtis JL, Austin JHM, Grenier PA, Kauczor HU, Bailey W, DeMeo D, Casaburi RH, Friedman P, van Beek EJR, Hokanson JE, Bowler RP, Beaty TH, Washko GR, Han MK, Kim V, Kim SS, Yagihashi K, Washington L, McEvoy C, Tanner C, Mannino DM, Make BJ, Silverman EK, Crapo JD, COPDGene Investigators. Clinical and radiologic disease in smokers with normal spirometry. JAMA Intern Med 2015 Sep 1; 175(9):1539-49. PMID: 26098755, PMC4564354. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564354/

153.         Hayden LP, Hobbs BD, Cohen RT, Wise RA, Checkley W, Crapo JD, Hersh CP, COPDGene Investigators. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene Study. Respir Res 2015 Sept 21; 16:115. PMID: 26392057, PMC4578796. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578796/

154.         Vaz Fragoso CA, McAvay G, Van Ness PH, Casaburi R, Jensen RL, MacIntyre N, Gill TM, Yaggi HK, Concato J. Phenotype of normal spirometry in an aging population. Am J Respir Crit Care Med 2015 Oct 1; 192(7):817-25. PMID: 26114439, PMC4613896. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613896/

155.         Lynch DA, Austin JHM, Hogg JC, Grenier PA, Kauczor HU, Bankier AA, Barr RG, Colby TV, Galvin JR, Gevenois PA, Coxson H, Hoffman EA, Newell JD, Pistolesi M, Silverman EK, Crapo JD. CT definable subtypes of COPD: A statement of the Fleischner Society. Radiology 2015 Oct; 277(1):192-205. PMID: 25961632, PMC4613878. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613878/

156.         Fenster BE, Holm KE, Weinberger HD, Moreau KL, Meschede K, Crapo JD, Make BJ, Bowler RP, Wamboldt FS, Hoth KF. Right ventricular diastolic function and exercise capacity in COPD. Respir Med 2015 Oct; 109(10):1287-92. PMID: 26371994, PMC4745988. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745988/

157.         Hancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. Transl Psychiatry 2015 Oct 6; 5:e651. PMID: 26440539, PMC4930126. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930126/

158.         Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estépar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H, Hunninghake GM. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med 2015 Oct 29; 15:134. PMID: 26514822, PMC4625729. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625729/

159.         Valipour A, Shah PL, Gesierich W, Eberhardt R, Snell G, Strange C, Barry R, Gupta A, Henne E, Bandyopadhyay S, Raffy P, Yin Y, Tschirren J, Herth FJF. Patterns of emphysema heterogeneity. Respiration 2015 Nov; 90(5):402-11. PMID: 26430783, PMC4756593. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756593/

160.         Qiu W, Wan E, Morrow J, Cho MH, Crapo JD, Silverman EK, DeMeo DL. The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study. Epigenetics 2015 Nov 2; 10(11):1064-73. PMID: 26646902, PMC4844199. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844199/

161.         Lutz SM, Cho MH, Hersh CP, Castaldi P, McDonald M, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas D, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird N, Lange C, Hokanson JE, Silverman EK, ECLIPSE Investigators, COPDGene Investigators. A genome-wide association study identifies novel risk loci for spirometric measures among smokers of European and African Ancestry. BMC Genet. 2015 Dec 3; 16:138. PMID: 26634245, PMC4668640. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668640/

162.         Begum F, Ruczinski I, Li S, Silverman EK, Cho MH, Lynch DA, Curran-Everett D, Crapo J, Scharpf RB, Parker MM, Hetmanski JB, Beaty TH on behalf of the COPDGene investigators. Identifying a deletion affecting total lung capacity among subjects in the COPDGene study cohort. Genet Epidemiol. 2016 Jan; 40(1):81-8. PMID: 26643968, PMC4679532. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679532/

163.         Bhatt SP, Wells JM, Kinney GL, Washko GR, Budoff M, Kim YI, Bailey WC, Nath H, Hokanson JE, Silverman EK, Crapo JD, Dransfield MR, for the COPDGene Investigators. β-blockers are associated with a reduction in COPD exacerbations. Thorax 2016 Jan; 71(1):8-14. PMID: 26283710, PMC5154678. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154678/

164.         Hardin M, Foreman M, Dransfield MT, Hansel N, Han MK, Cho MH, Bhatt SP, Ramsdell J, Lynch D, Curtis JL, Silverman EK, Washko G, DeMeo D; COPDGene Investigators. Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J 2016 Jan; 47(1):104-12. PMID: 26541532, PMC5374719. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374719/

165.         Zach JA, Williams A, Jou SS, Yagihashi K, Everett D, Hokanson JE, Stinson D, Lynch DA; COPDGene Investigators. Current smoking status is associated with lower quantitative CT measures of emphysema and gas trapping. J Thorac Imaging 2016 Jan; 31(1):29-36. PMID: 26429588, PMC4677600. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677600/

166.         Gallardo-Estrella L, Lynch DA, Prokop M, Stinson D, Zach J, Judy PF, van Ginneken B, van Rikxoort EM. Normalizing computed tomography data reconstructed with different filter kernels: effect on emphysema quantification. Eur Radiol 2016 Feb; 26(2):478-86. PMID: 26002132, PMC4761317. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712239

167.         Bhatt SP, Terry NL, Nath H, Zach JA, Tschirren J, Bolding MS, Stinson DS, Wilson CG, Curran-Everett D, Lynch DA, Putcha N, Soler X, Wise RA, Washko GR, Hoffman EA, Foreman MG, Dransfield MT, Genetic Epidemiology of COPD (COPDGene) Investigators. Association between expiratory central airway collapse and respiratory outcomes among smokers. JAMA 2016 Feb 2; 315(5):498-505. PMID: 26836732, PMC5173387. http://www.ncbi.nlm.nih.gov/pubmed/26836732

168.         Busch R, Han MK, Bowler RP, Dransfield MT, Wells JM, Regan EA, Hersh CP; COPDGene Investigators. Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med 2016 Feb 10; 16(1):28. PMID: 26861867, PMC4748594. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748594/

169.         Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, Okajima Y, Dupuis J, Latourelle JC, Cho MH, El-Chemaly S, Coxson HO, Celli BR, Fernandez IE, Zazueta OE, Ross JC, Harmouche R, Estépar RS, Diaz AA, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Budoff MJ, Kinney GL, Hokanson JE, Williams MC, Murchison JT, MacNee W, Hoffmann U, O'Donnell CJ, Launer LJ, Harrris TB, Gudnason V, Silverman EK, O'Connor GT, Washko GR, Rosas IO, Hunninghake GM; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators; COPDGene Investigators. Association between interstitial lung abnormalities and all-cause mortality. JAMA 2016 Feb 16; 315(7):672-81. PMID: 26881370, PMC4828973. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828973/

170.         Chang Y, Glass K, Liu YY, Silverman EK, Crapo JD, Tal-Singer R, Bowler R, Dy J, Cho M, Castaldi P. COPD subtypes identified by network-based clustering of blood gene expression. Genomics 2016 Mar; 107(2-3):51-8. PMID: 26773458, PMC4761317. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761317/

171.         Chan KS, Jiao F, Mikulski MA, Gerke A, Guo J, Newell JD Jr, Hoffman EA, Thompson B, Lee CH, Fuortes LJ. Novel logistic regression model of chest CT attenuation coefficient distributions for the automated detection of abnormal (emphysema or ILD) versus normal lung. Acad Radiol 2016 Mar; 23:304-14. PMID: 26776294, PMC4744594. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744594/

172.         Leidy NK, Malley KG, Steenrod AW, Mannino DM, Make BJ, Bowler RP, Thomashow BM, Barr RG, Rennard SI, Houfek JF, Yawn BP, Han MK, Meldrum CA, Bacci ED, Walsh JW, Martinez F. Insight into best variables for COPD case identification: a random Forests analysis. Chronic Obstr Pulm Dis (Miami) 2016 Jan; 3(1):406-418. PMID: 26835508, PMC4729451. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729451/

173.         Vaz Fragoso CA, McAvay G, Van Ness PH, Casaburi R, Jensen RL, MacIntyre N, Yaggi HK, Gill TM, Concato J. Phenotype of spirometric impairment in an aging population. Am J Respir Crit Care Med 2016 April 1; 193(7):727-735. PMID: 26540012, PMC4824933. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824933/

174.         Harmouche R, Ross JC, Diaz AA, Washko GR, Estepar RS. A robust emphysema severity measure based on disease subtypes. Acad Radiol 2016 Apr; 23(4)421-8. PMID: 26947221, PMC4813794. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813794/

175.         Martinez CH, Diaz AA, Parulekar AD, Rennard SI, Kanner RE, Hansel NN, Couper D, Holm KE, Hoth KF, Curtis JL, Martinez FJ, Hanania NA, Regan EA, Paine R 3rd, Cigolle CT, Han MK, COPDGene and SPIROMICS Investigators. Age-related differences in health-related quality of life in COPD: an analysis of the COPDGene and SPIROMICS cohorts. Chest 2016 Apr; 149(4):927-35. PMID: 26304104, PMC4767697. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944781/

176.         Ouyang W, Dass C, Zhao H, Kim C, Criner G; COPDGene Investigators. Multiplanar MDCT measurement of esophageal hiatus surface area: association with hiatal hernia and GERD. Surg Endosc 2016 Jun; 30(6):2465-72. PMID: 26304104, PMC4767697. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767697/

177.         Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA. Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs. Nat Immunol 2016 Jun; 17(6):626-35. PMID: 27111143, PMC5345745. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345745

178.         Lu Q, Jin C, Sun J, Bowler RP, Kechris K, Kaminski N, Zhao H. Post-GWAS prioritization through data integration provides novel insights on chronic obstructive pulmonary disease. Stat Biosci 2016 Jun 13; 2016:1-17 [Epub]. PMID: 27812370, PMC5087812. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087812

179.         Fingerlin T, Zhang W; Yang I, Ainsworth HC, Russell PH, Blumhagen RZ, Schwarz MI, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S, Collard HR, Wolters PJ, Bradford WZ, Kossen K, Seiwert SD, du Bois RM, Garcia CK, Devine MS, Gudmundsson G, Isaksson HJ, Kaminski N, Zhang Y, Gibson KF, Lancaster LH, Maher TM; Molyneaux PL, Wells AU, Moffatt MF, Selman M, Pardo A, Kim DS, Crapo JD, Make BJ, Regan EA, Walek DS, Daniel JJ, Kamatani Y, Zelenika D, Murphy E, Smith K, McKean D, Pedersen BS, Talbert J, Powers J, Markin CR, Beckman KB, Lathrop M, Freed B, Langefeld CD, Schwartz DA. Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia. BMC Genetics 2016 Jun 7; 17(1):74. PMID: 27266705, PMC4895966. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895966/

180.         Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH, Lung GO, COPDGene Investigators, NHLBI Exome Sequencing Project. Exome sequencing analysis in severe, early onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016 June 15; 193(12):1353-1363. PMID: 26736064, PMC4910887. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910887/

181.         Krachman SL, Tiwari R, Vega ME, Yu D, Soler X, Jaffe F, Kim V, Swift I, D'Alonzo GE, Criner GJ; COPDGene Investigators. Effect of emphysema severity on the apnea-hypopnea index in smokers with obstructive sleep apnea. Ann Am Thorac Soc 2016 Jul; 13(7):1129-35. PMID: 27078132, PMC5015748. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015748/

182.         Kim V, Zhao H, Boriek AM, Anzueto A, Soler X, Bhatt SP, Rennard SI, Wise R, Comellas A, Ramsdell JW, Kinney GL, Han MK, Martinez CH, Yen A, Black-Shinn J, Porszasz J, Criner GJ, Hanania NA, Sharafkhaneh A, Crapo JD, Make BJ, Silverman EK, Curtis JL; COPDGene Investigators. Persistent and newly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease. Ann Am Thorac Soc 2016 July 1; 13(7):1016-25. PMID: 27158740, PMC5015750. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015750/

183.         Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics, ECLIPSE, COPDGene and International COPD Genetics Network Investigators. Exome array analysis identifies a common variant in IL27 associated with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016 Jul 1; 194(1):48-57. PMID: 26771213, PMC4960630. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960630/

184.         Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJR, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK, for the COPDGene Investigators. Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016 July 15; 194(2):178-84. PMID: 26808615, PMC5003216. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003216/

185.         Yip WK, Bonetti M, Cole BF, Barcella W, Wang XV, Lazar A, Gelber RD. Subpopulation treatment effect pattern plot (STEPP) analysis for continuous, binary, and count outcomes. Clin Trials 2016 Aug; 13(4):382-90. PMID: 27094489, PMC4942365. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942365

186.         Silverman EK. Risk of lung disease in PI MZ heterozygotes: current status and future directions. Ann Am Thorac Soc 2016 Aug; 13 (Suppl 4):S341-5. PMID: 27564671, PMC5059493. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059493

187.         Hardin M, Cho MH, McDonald ML, Wan E, Lomas DA, Coxson HO, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Bhatt S, Kim V, Ramsdell J, Regan EA, Make BJ, Hokanson JE, Crapo JD, Beaty TH, Hersh CP on behalf of the ECLIPSE and COPDGene Investigators. A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J 2016 Aug; 16(4):326-35. PMID: 26503814, PMC4848212. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848212/

188.         Sun W, Kechris K, Jacobson S, Hawkins GA, Yang J, Chen T, Quibrebra PM, Anderson W, Barr RG, Basta PV, Bleecker ER, Beaty T, Casaburi R, Castaldi P, Cho MH, Comellas A, Crapo JD, Criner G, Demeo D, Christenson SA, Couper DJ, Curtis JL, Doerschuk CM, Drummond MB, Freeman CM, Gouskova NA, Han MK, Hanania NA, Hansel NN, Hersh CP, Hoffman EA, Kaner RJ, Kanner RE, Kleerup EC, Lutz S, Martinez FJ, Meyers DA, Peters SP, Regan EA, Rennard SI, Scholand MB, Woodruff PG, Silverman EK, O'Neal WK, Bowler RP, for the SPIROMICS Research Group and COPDGene Investigators. Common genetic polymorphisms influence blood biomarker associations in COPD. PLoS Genet. 2016 Aug 17; 12(8):e1006011. PMID: 27532455, PMC4988740. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988780/

189.         Cosentino J, Zhao H, Hardin M, Hersh CP, Crapo JD, Kim V, Criner GJ, and the COPDGene Investigators. Analysis of asthma-chronic obstructive pulmonary disease overlap syndrome when defined on the basis of bronchodilator response and degree of emphysema. Ann Am Thorac Soc 2016 Sept 1; 13(9):1483-89. PMID: 27268723, PMC5614769. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614769

190.         Adami A, Cao R, Porszasz J, Casaburi R, Rossiter HB. Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD. Respir Physiol Neurobiol 2016 Sep 19; 235:18-26. PMID: 27659351, PMC5136338 [Available on 2018-01-01]. https://www.ncbi.nlm.nih.gov/pubmed/27659351

191.         Bhatt SP, Bodduluri D, Newell JD, Hoffman EA, Sieren JC, Han MK, Dransfield MT, Reinhardt JM, COPDGene Investigators. CT-derived biomechanical metrics improve agreement between spirimetry and emphysema. Acad Radiol 2016 Oct; 23(10):1255-63. PMID: 27055745, PMC5026854. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026854

192.         Morrow JD, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Glass K, Choi AM, Quackenbush J, Silverman EK, DeMeo DL. DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics 2016 Oct; 10(11):730-739. PMID: 27564456, PMC5094634.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094634/

193.         Begum F, Ruczinski I, Hokanson JE, Lutz SM, Parker MM, Cho MH, Hetmanski JB, Scharpf RB, Crapo JD, Silverman EK, Beaty TH on behalf of the COPDGene investigators. Hemi­zygous deletion on chromosome 3p26.1 is associated with heavy smoking among African American subjects in the COPDGene study. PLoS One. 2016 Oct 6; 11(10):e0164134. PMID: 27711239, PMC5053531. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164134

194.         Kinney GL, Baker EH, Klein OL, Black-Shinn JL, Wan ES, Make B, Regan E, Bowler RP, Lutz SM, Young KA, Duca LM, Washko GR, Silverman EK, Crapo JD, Hokanson JE. Pulmonary predictors of incident diabetes in smokers. Chronic Obstr Pulm Dis 2016 Oct; 3(4):739-47. PMID: 27795984, PMC5084840. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084840

195.         Kessler MD, Yerges-Armstrong L, Taub MA, Shetty AC, Maloney K, Jeng LJ, Ruczinski I, Levin AM, Williams LK, Beaty TH, Mathias RA, Barnes KC; Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), O'Connor TD. Challenges and disparities in the application of personalized genomic medicine to populations with African ancestry. Nat Commun 2016 Oct 11; 7:12521. PMID: 27725664, PMC5062569. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062569/

196.         Mathias RA, Taub MA, Gignoux CR, Fu W, Musharoff S, O'Connor TD, Vergara C, Torgerson DG, Pino-Yanes M, Shringarpure SS, Huang L, Rafaels N, Boorgula MP, Johnston HR, Ortega VE, Levin AM, Song W, Torres R, Padhukasahasram B, Eng C, Mejia-Mejia DA, Ferguson T, Qin ZS, Scott AF, Yazdanbakhsh M, Wilson JG, Marrugo J, Lange LA, Kumar R, Avila PC, Williams LK, Watson H, Ware LB, Olopade C, Olopade O, Oliveira R, Ober C, Nicolae DL, Meyers D, Mayorga A, Knight-Madden J, Hartert T, Hansel NN, Foreman MG, Ford JG, Faruque MU, Dunston GM, Caraballo L, Burchard EG, Bleecker E, Araujo MI, Herrera-Paz EF, Gietzen K, Grus WE, Bamshad M, Bustamante CD, Kenny EE, Hernandez RD, Beaty TH, Ruczinski I, Akey J; CAAPA., Barnes KC. A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. Nat Commun 2016 Oct 11; 7:12522. PMID: 27725671, PMC5062574. https://www.ncbi.nlm.nih.gov/pubmed/27725671

197.         Dilektasli AG, Porszasz J, Casaburi R, Stringer WW, Bhatt SP, Pak Y, Rossiter HB, Washko G, Castaldi PJ, San Jose Estepar R, Hansen JE; COPDGene Investigators. A novel spirometric measure identifies mild chronic obstructive pulmonary disease unidentified by standard criteria. Chest 2016 Nov; 150(5):1080-90. PMID: 27452770, PMC5103018. http://www.ncbi.nlm.nih.gov/pubmed/27452770/

198.         Ginsburg SB, Zhao J, Humphries S, Jou S, Yagihashi K, Lynch DA, Schroeder JD, COPDGene Investigators. Texture-based quantification of centrilobular emphysema and centrilobular nodularity in longitudinal CT scans of current and former smokers. Acad Radiol 2016 Nov; 23(11):1349-1358. PMID: 27575837, PMC5096977 [Available on 2017-11-01]. http://www.ncbi.nlm.nih.gov/pubmed/27575837

199.         Nambu A, Zach J, Schroeder J, Jin G, Kim SS, Kim YI, Schnell C, Bowler R, Lynch DA. Quantitative computed tomography measurements to evaluate airway disease in chronic obstructive pulmonary disease: Relationship to physiologic measure­ments, clinical index and visual assessment of airway disease. Eur J Radiol 2016 Nov; 85(11):2144-55. PMID: 27776670, PMC5310933. http://www.ncbi.nlm.nih.gov/pubmed/27776670

200.         Rahaghi FN, Wells JM, Come CE, De La Bruere IA, Bhatt SP, Ross JC, Vegas-Sánchez-Ferrero G, Diaz AA, Minhas J, Dransfield MT, San José Estépar R, Washko GR; and the COPDGene Investigators. Arterial and venous pulmonary vascular morphology and their relationship to findings in cardiac magnetic resonance imaging in smokers. J Comput Assist Tomogr 2016 Nov/Dec; 40(6):948-952. PMID: 27636250, PMC5110399 [Available on 2017-11-01]. https://www.ncbi.nlm.nih.gov/pubmed/27636250

201.         Wells JM, San Jose Estepar R, McDonald MN, Bhatt SP, Diaz AA, Bailey WC, Jacobson FL, Dransfield MT, Washko GR, Make BJ, Casaburi RH, Van Beek EJR, Hoffman EA, Sciurba FC, Crapo JD, Silverman EK, Hersh CP, and the COPDGene Investigators. Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med 2016 Dec 1; 16(1):169. PMID: 27903260, PMC5131397. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131397/

202.         McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST; CAMP Research Group. Genetics and genomics of longitudinal lung function patterns in individuals with asthma. Am J Respir Crit Care Med 2016 Dec 15; 194(12):1465-1474. PMID: 27367781, PMC5215031 [Available on 2017-12-15]. http://www.ncbi.nlm.nih.gov/pubmed/27367781/

203.         Hayden LP, Cho MH, McDonald MN, Crapo JD, Beaty TH, Silverman EK, Hersh CP. Susceptibility to childhood pneumonia: A genome wide analysis. Am J Respir Cell Mol Biol 2017 Jan; 56(1):20-28. PMID: 27508494, PMC5248961. http://www.ncbi.nlm.nih.gov/pubmed/27508494/

204.         Halper-Stromberg E, Cho MH, Wilson C, Nevrekar D, Crapo JD, Washko G, San Jose Estepar R, Lynch DA, Silverman EK, Leach S, Castaldi PJ. Visual assessment of chest CT images is independently useful for genetic association analysis in studies of chronic obstructive pulmonary disease. Ann Am Thorac Soc 2017 Jan 1; 14(1):33-40. PMID: 27739898, PMC5291477 [Available on 2018-01-01]. https://www.ncbi.nlm.nih.gov/pubmed/27739898

205.         Diaz AA, Young TP, Maselli DJ, Martinez CH, Maclean ES, Yen A, Dass C, Simpson SA, Lynch DA, Kinney GL, Hokanson JE, Washko GR, San Jose Estepar R. Bronchoarterial ratio in never-smoker adults: implications for bronchial dilation definition. Respirology 2017 Jan; 22(1):108-113. PMID: 27538197, PMC5161710. https://www.ncbi.nlm.nih.gov/pubmed/27538197

206.         Lambert AA, Putcha N, Drummond MB, Boriek AM, Hanania NA, Kim V, Kinney GL, McDonald MN, Brigham EP, Wise RA, McCormack C, Hansel NN; COPDGene Investigators. Obesity is associated with increased morbidity in moderate to severe COPD. Chest 2017 Jan; 151(1):68-77. PMID: 27568229, PMC5310126 [Available on 2018-01-01]. http://www.ncbi.nlm.nih.gov/pubmed/27568229/

207.         Ross JC, Castaldi PJ, Cho MH, Chen J, Chang Y, Dy JG, Silverman EK, Washko GR, Jose Estepar RS. A Bayesian nonparametric model for disease subtyping: application to emphysema phenotypes. IEEE Trans Med Imaging 2017 Jan; 36(1):343-354. PMID: 28060702, PMC5267575. https://www.ncbi.nlm.nih.gov/pubmed/28060702

208.         Bihlet AR, Karsdal MA, Sand JM, Leeming DJ, Roberts M, White W, Bowler R. Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD. Respir Res 2017 Jan 19; 18(1):22. PMID: 28103932, PMC5248528. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248528/

209.         Dransfield MT, Kunisaki KM, Strand MJ, Roark SE, Bhatt SP, Wells JM, Criner GJ, Bowler RP, Make BJ, for the COPDGene Investigators. Acute exacerbations and lung function loss in smokers with and without COPD. Am J Respir Crit Care Med 2017 Feb 1; 195(3):324-330. PMID: 27556408, PMC5328181 [Available on 2018-02-01]. http://www.ncbi.nlm.nih.gov/pubmed/27556408/

210.         Lutz SM, Fingerlin TE, Hokanson JE, Lange C. A general approach to testing for pleiotropy with rare and common variants. Genet Epidemiol 2017 Feb; 41(2):163-170. PMID: 27900789, PMC5472207. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472207/

211.         Keene JD, Jacobson S, Kechris K, Kinney GL, Foreman MG, Doerschuk CM, Make BJ, Curtis JE, Rennard SI, Barr RG, Bleecker ER, Kanner RE, Kleerup EC, Hansel NN, Woodruff PG, Han MK, Paine III R, Martinez FJ, Bowler RP, O'Neal WK for COPDGene and SPIROMICS Investigators. Biomarkers predictive of exacerbations in the SPIROMICS and COPDGene cohorts. Am J Respir Crit Care Med 2017 Feb 15; 195(4):473-481. PMID: 27579823, PMC5378424 [Available on 2018-02-15]. http://www.ncbi.nlm.nih.gov/pubmed/27579823/

212.         Martinez CH, Diaz AA, Meldrum C, Curtis JL, Cooper CB, Pirozzi C, Kanner RC, Paine R, Woodruff PG, Bleecker ER, Hansel NN, Barr RG, Marchetti N, Criner GJ, Kazerooni EA, Hoffman EA, Ross BD, Galban CJ, Cigolle CT, Martinez FJ, Han MK. Age and small airway imaging abnormalities in subjects with and without airflow obstruction in SPIROMICS. Am J Respir Crit Care Med 2017 Feb 15; 195(4):464-72. PMID: 27564413, PMC5378423 [Available on 2018-02-15]. https://www.ncbi.nlm.nih.gov/pubmed/27564413

213.         Martinez CH, Freeman CM, Nelson JD, Murray S, Wang X, Budoff MJ, Dransfield MT, Hokanson JE, Kazerooni EA, Kinney GL, Martinez FJ, Regan EA, Wells JM, Han MK, Curtis JL, COPDGene Investigators. GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res 2017 Feb 28; 18(1):42. PMID: 28245821, PMC5331711. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331711/

214.         Wain LV, Shrine N, Soler Artigas M, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington RL, Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP, Understanding Society Scientific Group, Campbell A, Porteous DJ, Jarvelin M, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson FJ, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, Kähönen M, Surakka I, Vitart V, Hayward C, Lehtimäki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Bossé Y, Joubert P, van den Berge M, Brandsma C, Paré PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL, Geisinger-Regeneron DiscovEHR Collaboration, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJF, Walters WG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho MH, Silverman EK, Sayers I, Trynka G, Morris AP, Strachan DP, Hall IP, Tobin MD. Genome-wide association for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet 2017 Mar; 49(3):416-425. PMID: 28166213, PMC5326681. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681/

215.         Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine NRG, Artigas MS, Jackson VE, Wain LV, Hall IP, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh Y, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang X, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH, COPDGene Investigators, ECLIPSE Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigators, LifeLines Investigators, SPIROMICS Research Group, International COPD Genetics Network Investigaors, UK BiLEVE Investigators, International COPD Genetics Consortium. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet 2017 Mar; 49(3):426-432. PMID: 28166215, PMC5381275. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275/

216.         Hardin ME, Cho MH, Sharma SS, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo J, Beaty TH, Laird N, Silverman EK, DeMeo DL and the COPDGene and ECLIPSE Investigators. Sex-based genetic association identifies CELSR1 as a possible COPD risk locus among women. Am J Respir Cell Mol Biol 2017 Mar; 56(3):332-341. PMID: 27854507, PMC5359539 [Available on 2018-03-01]. https://www.ncbi.nlm.nih.gov/pubmed/27854507

217.         Morrow JD, Zhou X, Lao T, Jiang Z, DeMeo DL, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Choi AM, Silverman EK, Hersh CP. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep 2017 Mar 13; 7:44232. PMID: 28287180, PMC5347019. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347019/

218.         Martinez FJ, Mannino D, Leidy NK, Malley KG, Bacci ED, Barr RG, Bowler RP, Han MK, Houfek JF, Make B, Meldrum CA, Rennard S, Thomashow B, Walsh J, Yawn BP; High-Risk-COPD Screening Study Group. A new approach for identifying patients with undiagnosed chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2017 Mar 15; 195(6):748-756. PMID: 27783539, PMC5363964 [Available 2018-03-15]. https://www.ncbi.nlm.nih.gov/pubmed/27783539

219.         Boueiz A, Lutz SM, Cho MH, Hersh CP, Bowler RP, Washko GR, Halper-Stromberg E, Bakke P, Gulsvik A, Laird NM, Beaty TH, Coxson HO, Crapo JD, Silverman EK, Castaldi PJ, DeMeo DL, for COPDGene and ECLIPSE Investigators. Genome-wide association study of the genetic determinants of emphysema distribution. Am J Respir Crit Care Med 2017 Mar 15; 195(6):757-71. PMID: 27669027, PMC5363968 [Available on 2018-03-15]. https://www.ncbi.nlm.nih.gov/pubmed/27669027

220.         Washko GR, Kinney GL, Ross JC, San José Estépar R, Han MK, Dransfield MT, Kim V, Hatabu H, Come CE, Bowler RP, Silverman EK, Crapo J, Lynch DA, Hokanson J, Diaz AA; COPDGene Investigators. Lung mass in smokers. Acad Radiol 2017 Apr; 24(4):386-392. PMID: 27940230, PMC5600161 [Available on 2018-04-01]. PMID: 27940230. https://www.ncbi.nlm.nih.gov/pubmed/27940230

221.         Hodgson S, Griffin T, Reilly C, Harvey S, Witthuhn B, Sandri B, Kunisaki KM, Wendt CH. Plasma sphingolipids in HIV-associated chronic obstructive pulmonary disease. BMJ Open Respir Res 2017 Apr 3; 4(1):e000180. PMID: 28409005, PMC5387954. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387954/

222.         Westney G, Foreman MG, Xu J, Henriques King M, Flenaugh E, Rust G. Impact of comorbidities among Medicaid enrollees with chronic obstructive pulmonary disease, United States, 2009. Prev Chronic Dis 2017 Apr 13; 14:E31. PMID: 28409741, PMC5392445. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392445/

223.         Farahi N, Paige E, Balla J, Prudence E, Ferreira RC, Southwood M, Appleby SL, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Silverman EK, Cho MH, Danesh J, Paul DS, Freitag DF, Chilvers ER. Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. Hum Mol Genet 2017 Apr 15; 26(8):1584-1596. PMID: 28334838, PMC5393150. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393150/

224.         Johnston HR, Hu YJ, Gao J, O'Connor TD, Abecasis GR, Wojcik GL, Gignoux CR, Gourraud PA, Lizee A, Hansen M, Genuario R, Bullis D, Lawley C, Kenny EE, Bustamante C, Beaty TH, Mathias RA, Barnes KC, Qin ZS; CAAPA Consortium. Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 2017 Apr 21; 7:46398. PMID: 28429804, PMC5399604. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399604/

225.         Bodduluri S, Bhatt SP, Hoffman EA, Newell JD Jr, Martinez CH, Dransfield MT, Han MK, Reinhardt JM; COPDGene Investigators. Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax 2017 May; 72(5):409-414. PMID: 28044005, PMC5526353 [Available on 2018-05-01]. https://www.ncbi.nlm.nih.gov/pubmed/28044005

226.         Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs B, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH. Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol 2017 May; 41(4):309-319. PMID: 28191685, PMC5397337 [Available on 2018-05-01]. https://www.ncbi.nlm.nih.gov/pubmed/28191685

227.         Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol 2017 May; 41(4):332-340. PMID: 28318110, PMC5525021. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525021

228.         Rahaghi FN, Sánchez-Ferrero GV, Minhas JK, Come CE, De La Bruere I, Wells JM, González-Serrano G, Bhatt SP, Fenster BE, Diaz AA, Kohli P, Ross JC, Lynch DE, Dransfield MT, Bowler RP, Ledesma-Carbayo MJ, San José Estépar R, Washko GR, COPDGene Investigators. Ventricular geometry from non-contrast non-ECG-gated CT scans: an imaging marker of cardiopulmonary disease in smokers. Acad Radiol 2017 May; 24(5):594-602. PMID: 28215632, PMC5653289 [Available on 2018-05-01]. https://www.ncbi.nlm.nih.gov/pubmed/28215632

229.         Manichaikul A, Sun L, Borczuk AC, Onengut-Gumuscu S, Farber EA, Mathai SK, Zhang W, Raghu G, Kaufman JD, Hinckley-Stukovsky KD, Kawut SM, Jelic S, Liu W, Fingerlin TE, Schwartz DA, Sell JL, Rich SS, Barr RG, Lederer DJ. Plasma soluble receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Ann Am Thorac Soc 2017 May; 14(5):628-635. PMID: 28248552, PMC5427736 [Available 2018-05-01]. https://www.ncbi.nlm.nih.gov/pubmed/28248552

230.         Diaz AA, Young TP, Maselli DJ, Martinez CH, Gill R, Nardelli P, Wang W, Kinney GL, Hokanson JE, Washko GR, San Jose Estepar R. Quantitative CT measures of bronchiectasis in smokers. Chest 2017; 151(6):1255-1262. PMID: 27890712. https://www.ncbi.nlm.nih.gov/pubmed/27890712

231.         Hoff BA, Pompe E, Galbán S, Postma DS, Lammers JJ, Ten Hacken NHT, Koenderman L, Johnson TD, Verleden SE, de Jong PA, Mohamed Hoesein FAA, van den Berge M, Ross BD, Galbán CJ. CT-based local distribution metric improves characterization of COPD. Sci Rep 2017 Jun 7; 7(1):2999. PMID: 28592874, PMC5462827. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462827/

232.         Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Tal-Singer R, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Paré PD, Levy RD, Rennard SI, Beaty TH, Hokanson J, Silverman EK, and Cho MH, for the NETT Genetics, ECLIPSE, ICGN, and COPDGene Investigators. Genetic association and risk scores in a COPD meta-analysis of 16,707 subjects. Am J Respir Crit Mol Biol 2017 Jul; 57(1):35-46. PMID: 28170284, PMC5516277. https://www.ncbi.nlm.nih.gov/pubmed/28170284

233.         Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella M, Silverman EK, Zhou X, Hersh CP. Transcriptomic analysis of lung tissue from cigarette smoke induced emphysema murine models and human COPD show shared and distinct pathways. Am J Respir Cell Mol Biol 2017 Jul; 57(1):47-58. PMID: 28248572, PMC5516276. https://www.ncbi.nlm.nih.gov/pubmed/28248572

234.         Ash SY, Harmouche R, Ross JC, Diaz AA, Hunninghake GM, Putman RK, Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, Estepar RS, Washko GR. The objective identification and quantification of interstitial lung abnormalities in smokers. Acad Radiol 2017 Aug; 24(8):941-946. PMID 27989445, PMC5472510 [Available on 2018-06-15]. https://www.ncbi.nlm.nih.gov/pubmed/27989445

235.         Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH, Ziniti J, Curran-Everett D, Criner G, Hokanson JE, Brantly M, Rouhani FN, Sandhaus RA, Crapo JD, Silverman EK, the COPDGene Investigators. Alpha-1 antitrypsin PiMZ genotype is associated with COPD in two racial groups. Ann Am Thorac Soc 2017 Aug; 14(8):1280-1287. PMID: 28380308, PMC5566271 [Available 2018-08-01]. https://www.ncbi.nlm.nih.gov/pubmed/28380308

236.         Bhatt SP, Bodduluri S, Hoffman EA, Newell Jr JD, Sieren JC, Dransfield MT, Reinhardt JM, COPDGene Investigators. CT measure of lung at-risk and lung function decline in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2017 Sep 1; 196(5):569-576. PMID: 28481639, PMC5620667 [Available on 2018-09-01].  https://www.ncbi.nlm.nih.gov/pubmed/28481639

237.         Radder JE, Gregory AD, Leme AS, Cho MH, Chu Y, Kelly NJ, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Beaty TH, Crapo JD, Silverman EK, Zhang Y, Berndt A, Shapiro SD. Variable susceptibility to cigarette smoke-induced emphysema in 34 inbred strains of mice implicates Abi3bp in emphysema susceptibility. Am J Respir Cell Mol Biol 2017 Sep 3; 57(3):367-375. PMID: 28441029, PMC5625220 [Available on 2018-09-01].  https://www.ncbi.nlm.nih.gov/pubmed/28441029

238.         Ash SY, Harmouche R, Putman RK, Ross JC, Diaz AA, Hunninghake GM, Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, San Jose Estepar R, Washko GR. Clinical and genetic associations of objectively identified interstitial changes in smokers. Chest 2017 Oct; 152(4):780-791. PMID: 28506611. https://www.ncbi.nlm.nih.gov/pubmed/28506611

239.         Parker MM, Chase RP, Lamb A, Reyes A, Saferali A, Yun JH, Himes BE, Silverman EK, Hersh CP, Castaldi PJ. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics 2017 Oct 6; 10(1):58. PMID: 28985737. https://www.ncbi.nlm.nih.gov/pubmed/28985737

240.         Castaldi PJ, Benet M, Petersen H, Rafaels N, Finigan J, Paoletti M, Boezen HM, Vonk JM, Bowler R, Pistolesi M, Puhan MA, Anto J, Wauters E, Lambrechts D, Janssens W, Bigazzi F, Camiciottoli G, Cho MH, Hersh CP, Barnes K, Rennard S, Boorgula MP, Dy J, Hansel NH, Crapo JD, Tesfaigzi Y, Agusti A, Silverman EK, Garcia-Aymerich J. Do COPD subtypes really exist? COPD heterogeneity and clustering in ten independent cohorts. Thorax 2017 Nov; 72(11):998-1006. PMID: 28637835. https://www.ncbi.nlm.nih.gov/pubmed/28637835

241.         Martinez CH, Diaz AA, Meldrum CA, MacDonald MN, Murray S, Kinney GL, Hokanson JE, Curtis JL, Bowler RP, Han MK, Washko GR, Regan EA, COPDGene Investigators. Handgrip strength in chronic obstructive pulmonary disease. Associations with acute exacerbations and body composition. Ann Am Thorac Soc 2017 Nov; 14(11):1638-1645. PMID: 29090990. https://www.ncbi.nlm.nih.gov/pubmed/29090990

242.         Bhatt SP, Vegas-Sánchez-Ferrero G, Rahaghi FN, MacLean ES, Gonzalez-Serrano G, Come CE, Kinney GL, Hokanson JE, Budoff MJ, Cuttica MJ, Wells JM, San José Estépar R, Washko GR. Cardiac morphometry on computed tomography and exacerbation reduction with β-blocker therapy in COPD. Am J Respir Crit Care Med 2017 Apr 25 [Epub ahead of print]. PMID: 28441027. https://www.ncbi.nlm.nih.gov/pubmed/28441027

243.         Labaki WW, Martinez CH, Martinez FJ, Galbán CJ, Ross BD, Washko GR, Barr RG, Regan EA, Coxson HO, Hoffman EA, Newell JD Jr, Curran-Everett D, Hogg JC, Crapo JD, Lynch DA, Kazerooni EA, Han MK. The role of chest computed tomography in the evaluation and management of the patient with COPD. Am J Respir Crit Care Med 2017 Jun 29 [Epub ahead of print]. PMID: 28661698. https://www.ncbi.nlm.nih.gov/pubmed/28661698

244.         Bodduluri S, Reinhardt JM, Hoffman EA, Newell JD, Nath H, Dransfield MT, Bhatt SP, for the COPDGene Investigators. Signs of gas trapping in normal lung density regions in smokers. Am J Respir Crit Care Med 2017 July 14 [Epub ahead of print]. PMID: 28707983. https://www.ncbi.nlm.nih.gov/pubmed/28707983

245.         Brunette AM, Holm KE, Wamboldt FS, Kozora E, Moser DJ, Make BJ, Crapo JD, Meschede K, Weinberger HD, Moreau KL, Bowler RP, Hoth KF. Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive lung disease. J Clin Exp Neuropsychol 2017 Aug 2 [Epub ahead of print]. PMID: 28766459. https://www.ncbi.nlm.nih.gov/pubmed/28766459

246.         Bowler RP, Hansel NN, Jacobson S, Barr RG, Make BJ, Han MK, O'Neal WK, Oelsner EC, Casaburi R, Barjaktarevic I, Cooper C, Foreman M, Wise RA, DeMeo DL, Silverman EK, Bailey W, Harrington KF, Woodruff PG, Drummond MB, for COPDGene and SPIROMICS Investigarors. Electronic cigarette use in US adults at risk for or with COPD: analysis from two observational cohorts. J Gen Intern Med 2017 Sep 7 [Epub ahead of print]. PMID: 28884423. https://www.ncbi.nlm.nih.gov/pubmed/28884423

247.         Boueiz A, Chang Y, Cho MH, Washko GR, San José Estépar R, Bowler RP, Crapo JD, DeMeo DL, Dy JG, Silverman EK, Castaldi PJ, COPDGene Investigators. Lobar emphysema distribution is associated with 5-year radiologic disease progression. Chest 2017 Sep 21 [Epub ahead of print]. PMID: 28943279. https://www.ncbi.nlm.nih.gov/pubmed/28943279

 

 

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