COPDGene Conferences and Workshops
Since its beginnings in 2007, part of the success of COPDGene has been a history of holding conferences and workshops where investigators meet in person to discuss ongoing research and future directions. These events revitalize the multi-institutional collaborations that have been so important to COPDGene. Each year in May a COPDGene Investigators Meeting is held in conjunction with the ATS International Conference. Each November COPDGene holds a two-day investigator meeting in either Boston or Denver, the two cities where the COPDGene principal investigators are based.
November 9, 2023, Workshop: Integrating Social Determinants of Health (SDOH) in COPDGene Analyses – Boston, MA
This workshop was focused on the impact of social determinants of health on COPD. It was led by Drs. Elizabeth Regan, Dawn DeMeo, and Niru Putcha. This was an opportunity for investigators performing work in this area to present their results and create expanded discussions from other investigators.
| AGENDA |
| Plenary Session |
| SDOH in Pulmonary Disease – Nadia Hansel |
| Techniques and Experiences in SDOH – Gabriela Oates |
| Epidemiology – Moderator: Niru Putcha |
| Social Determinants of Health Associated with Frailty – Kate Phillips |
| Associations between Neighborhood Deprivation, Anemia, and Clinical Outcomes in COPD – Yukiko Kunitomo |
| Application of the ERS/ATS Spirometry Standards and Race-neutral Equations in the COPDGene Study – Enrico Schiavi |
| Social Determinants of Health Associated with Changes in Depression and Anxiety Symptoms – Sharon Lutz |
| The Impact of Income and Race in COPD Progression: a Multistate Transition – Luz Sanchez-Romero |
| Imaging/DLCO – Moderator: Liz Regan |
| Impact of Social Determinants of Health on Accelerated Lung Function Decline – Gloria Westney |
| Understanding How Social Determinants of Health Impact Obtaining High Quality Diffusing Capacity Measurements – Aparna Balusubramanian |
| Area Deprivation Index (ADI) is Associated with Quantitative Computed Tomography (QCT) Derived Textures and Biomarkers of Systemic Inflammation – Joseph Reinhardt |
| Socioeconomic Deprivation Is Associated with Prevalence and Persistence of Airway Mucus Plugs in Patients with COPD – Sofia Mettler |
| O’mics – Moderator: Dawn DeMeo |
| Poverty May Drive Lung Function Disparities through Epigenetic Programming and Age Acceleration – Yichen Huang |
| Omic association with SDOH, and the subsequent medication of FEV1 – Claire Guo |
| Proteomic, Metabolomic, and Transcriptomic Associations with Social Vulnerability and Area Deprivation Indices – Iain Konigsberg |
| The Relative Impact of Polygenic Risk Scores and Social Determinants of Health on COPD – Luciana Vargas |
| Discussion: Putting It Together for the Future |
| Grant Writing and Manuscripts |
November 10, 2023, COPDGene Fall Investigators Meeting – Boston, MA
| AGENDA |
| Highlights and Change to NHLBI Contract – James Crapo and Ed Silverman |
| Patterns of Progression of COPD over 10 Years Progression to GOLD 2-4 – Kendra Young |
| Implementation of COPDGene Phase 4 – Barry Make and Elizabeth Regan ProtocolContract RequirementsStatus of Clinical Centers Beginning Subject VisitsNational Research Coordinators |
| Plans for COPDGene 2023/2024 Diagnostic Recommendations – James Crapo and Ed Silverman |
| Social Determinants of Health Workshop Summary and Conclusions – Dawn DeMeo, Niru Putcha and Elizabeth Regan |
| Recognition of National Lung Cancer Screen Day Current Status of Lung Cancer Screening – Ella KazerooniLung Cancer Research Opportunities in COPDGene |
| Imaging Update Update on Mucus Plugging – Pietro NardelliAutomatic Assessment of Airways and Occlusive Mucus in COPDGene – Rudolfs Latisenko, ThironaExploring the Relations between Pulmonary Arterial and Venous Phenotypes, Disease Severity and Mortality in COPDGene – Leticia Gallardo Estrella, ThironaPhoton Counting CT – Sean Fain, Ehsan Abadi |
| Metrics for Emphysema Progression Phase 2 to Phase 3 – Gonzalo Vegas |
| Environmental Air Pollution Data and COPDGene – James Crooks |
| Update on Genetics/Omics in COPDGene Epigenetic Updates – Camila Lopes-RamosRNA Sequencing and Emphysema – Adel El BoueizMetabolomic Updates – Claire Guo and Russell Bowler |
| Opportunity for PRISm Clinical Trial – James Crapo and Ed Silverman |
May 20, 2023, COPDGene Investigator Workshop – Crystal City, VA
| Welcome and Highlights – James Crapo and Ed Silverman |
| COPDGene 2023 – COPD Diagnostic Criteria – James Crapo and Kendra Young |
| Phase 3 Finalization and C4R Wave 3 Project – Barry Make and Elizabeth Regan |
| Phase 4 Implementation – NHLBI Contract Overview of Single IRB and Concepts, Collaborative Research Structure – Rafaella Hart/BRANYRequirements for Clinical Centers – Documents, Personnel – IRB structureAncillary Studies under the sIRB |
| Phase 4 Protocol and Implementation – Make/Regan Date for End of Phase 3 and Start of Phase 4What is New in the Protocol?Aging Subjects – AccomodationsIdentification (3 factor: name, address, DOB) of subjectsClinical Monitoring RequirementsPlans for Phase 4 Training for Coordinators: Friday, August 4 in Denver |
| Investigator Research Presentations – ATS Abstracts COPD Deep-Phenotype: Finding Single Radiographic Features for Prospective COPD Outcomes and Protein levels Prognostication – Ariel CurialeUnsupervised Discovery of Gene Expression Networks Associated with Pulmonary Function, Emphysema, and Smoking in COPDGene – Iain KonigsbergAirway Predominant COPD is Associated with Elevated Risk for Cognitive Impairment in Tobacco-Exposed Older Adults – Greg Kinney |
| Genetics and Omics – Critical Biomarkers for COPD Progression and Heterogeneity – Silverman/Bowler Proteomic Associations with Lung Function Decline –Lisa RuvunaOverlap between COPD Genetic Association Results and Transcriptional Quantitative Trait Loci – Aabida SaferaliUsing Omics and Omics Risk Scores for Drug Repositioning – Matthew Moll |
| Imaging – Critical Imaging Markers of COPD – Lynch Automated Measures of Airway-Artery Ratios across Different GOLD Classes: a COPDGene Pilot Study – Jean-Paul Charbonnier Feature-Based PRM for Robust Disease Classification in COPD – Sundaresh Ram |
| Updates and Plans for COPDGene Working Groups – Ed Silverman |